Restoring
Muscle Strength

Biomaterials for orthopedic trauma and reconstructive surgery

Volumetric Muscle Loss
Volumetric Muscle Loss description

The disabilities caused by Volumetric Muscle Loss overwhelm the body's ability to regenerate muscle, making VML irrecoverable.

The Scale of the Problem

90% of muscle conditions in medically retired, battlefield-injured Service Members are due to VML
$380.9B in U.S. Health spending on musculoskeletal injuries (2017)
Over 250,000 traumatic muscle injuries a year
Over 80% of delayed amputations are caused by muscle trauma

Why VML is Different

Normal Muscle Injury

The basal lamina remains intact, allowing stem cells to migrate and regenerate tissue naturally.

Volumetric Muscle Loss

The basal lamina is destroyed, removing the biological scaffold needed for regeneration. Without intervention, the body cannot restore lost muscle volume.

Volumetric Muscle Loss illustration

The Science Behind GenAssist:

46%
Muscle Strength Improvement
Porcine model study(Unpublished)
$295K
NSF Phase I SBIR
National Science Foundation
Research

Validated in preclinical studies

GenAssist was awarded a $295,000 Phase I SBIR grant from the National Science Foundation to test MyoSponge in a porcine model of muscle trauma, demonstrating a 46% improvement in muscle strength.

Study Model
Large animal porcine model of volumetric muscle loss
Funding
National Science Foundation SBIR Phase I

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